Regionally localized thinning of the cerebral cortex in schizophrenia
@article{Kuperberg2003RegionallyLT, title={Regionally localized thinning of the cerebral cortex in schizophrenia}, author={Gina R. Kuperberg and Matthew R. Broome and Philip K. McGuire and Anthony S. David and Mohammad Istiadjid Eddy and Fukujiro Ozawa and Donald C. Goff and W. Caroline West and S. C. R. Williams and Andre van der Woburn Kouwe and D. H. Salat and A M Dale and Bruce R. Fischl}, journal={Schizophrenia Research}, year={2003}, volume={60}, pages={199-200} }
923 Citations
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References
SHOWING 1-10 OF 59 REFERENCES
Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging.
- Medicine, PsychologyArchives of general psychiatry
- 1999
A new method to segment the entire neocortex into 48 topographically defined brain regions suggested the importance of the paralimbic areas and their connections with prefrontal brain regions in schizophrenia.
Volume changes in gray matter in patients with schizophrenia.
- Medicine, PsychologyThe American journal of psychiatry
- 2002
The finding that the smaller gray matter volume was more pronounced in older patients with schizophrenia may suggest progressive loss of cerebral gray matter in schizophrenia patients.
Focal gray matter density changes in schizophrenia.
- Psychology, MedicineArchives of general psychiatry
- 2001
Gray matter density is decreased in distinct focal areas in the brains of patients with schizophrenia or schizophreniform disorder, with a group-by-age interaction for density found in the left amygdala.
Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms.
- Psychology, MedicineThe American journal of psychiatry
- 2001
Anatomical abnormalities in these schizophrenic patients with marked negative symptoms were most evident in left hemispheric neocortical and limbic regions and related white matter tracts, compatible with models that depict schizophrenia as a supraregional disorder of multiple, distributed brain regions and the axonal connections between them.
A computational morphometric MRI study of schizophrenia: effects of hallucinations.
- Psychology, MedicineCerebral cortex
- 2002
MRI data confirm the utility of voxel-based morphometric methods in schizophrenia research and point towards disruption to a 'paralimbic' neural network, as underlying schizophrenic psychopathology in general, with abnormalities of the left insula specifically related to hallucinations.
Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel-based morphometry.
- Psychology, MedicineThe American journal of psychiatry
- 2002
Observations confirm an association between thalamocortical morphometric abnormalities and schizophrenia, consistent with theoretical models of primary pathoetiological dysfunction in filtering, integration, and information transfer processes in patients with schizophrenia.
Regional frontal abnormalities in schizophrenia: a quantitative gray matter volume and cortical surface size study
- Medicine, PsychologyBiological Psychiatry
- 2000
Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study.
- Medicine, PsychologyThe New England journal of medicine
- 1992
New MRI neuroimaging techniques are used to derive volume measurements and three-dimensional reconstructions of temporal-lobe structures in vivo in 15 right-handed men with chronic schizophrenia and 15 matched controls to discover the degree of thought disorder is related to the size of the reduction in volume of the left posterior superior temporal gyrus.
Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging.
- Psychology, MedicineBrain : a journal of neurology
- 2001
It is demonstrated that MTR abnormalities in the cortex can be detected in chronic schizophrenia that may reflect subtle neuropathological changes involving neurones or neuronal processes and longitudinal studies are needed to determine whether these abnormalities are related to disease progression or other disease manifestations such as cognitive changes.
Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.
- Psychology, BiologyCerebral cortex
- 2000
The data suggest that under certain conditions the physiological ramifications of dorsal PFC neuronal pathology in schizophrenia includes exaggerated and inefficient cortical activity, especially of lateral PFC.