Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression

@article{Gourley2008RegionallySR,
  title={Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression},
  author={Shannon L Gourley and Florence J. Wu and Drew D Kiraly and Jonathan E Ploski and Jane R. Taylor},
  journal={Biological Psychiatry},
  year={2008},
  volume={63},
  pages={353-359}
}
BACKGROUND Elevated phosphorylation of neurotrophin-regulated transcription factors, such as cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB), in the hippocampus has been proposed as a common mediator of antidepressant (ADT) efficacy in otherwise naive rodents. The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of… CONTINUE READING
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