Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community.

@article{Brickman2012RegionalWM,
  title={Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community.},
  author={Adam M. Brickman and Frank Anthony Provenzano and Jordan Muraskin and Jennifer Jaie Manly and Sonja Blum and Zoltan L Apa and Yaakov Stern and Truman R. Brown and Jos{\'e} Alejandro Luchsinger and Richard P. Mayeux},
  journal={Archives of neurology},
  year={2012},
  volume={69 12},
  pages={1621-7}
}
BACKGROUND New-onset Alzheimer disease (AD) is often attributed to degenerative changes in the hippocampus. However, the contribution of regionally distributed small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging, remains unclear. OBJECTIVE To determine whether regional WMHs and hippocampal volume predict incident AD in an epidemiological study. DESIGN A longitudinal community-based epidemiological study of older adults from… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Pathogenesis of leukoaraiosis: a review.

View 6 Excerpts
Highly Influenced

MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected ARCH NEUROL / VOL 69 (NO

MS Fernando, JE Simpson, F Matthews
DEC 2012 WWW.ARCHNEUROL.COM • 2012

Similar Papers

Loading similar papers…