Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle

@article{Yang2008RegionalVO,
  title={Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle},
  author={Ge Yang and Lisa Ann Cameron and Paul S Maddox and Edward D. Salmon and Gaudenz Danuser},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={182},
  pages={631 - 639}
}
Continuous poleward movement of tubulin is a hallmark of metaphase spindle dynamics in higher eukaryotic cells and is essential for stable spindle architecture and reliable chromosome segregation. We use quantitative fluorescent speckle microscopy to map with high resolution the spatial organization of microtubule flux in Xenopus laevis egg extract meiotic spindles. We find that the flux velocity decreases near spindle poles by approximately 20%. The regional variation is independent of… CONTINUE READING

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