Regional specificity of manganese accumulation and clearance in the mouse brain: implications for manganese-enhanced MRI.

@article{Grnecker2013RegionalSO,
  title={Regional specificity of manganese accumulation and clearance in the mouse brain: implications for manganese-enhanced MRI.},
  author={Barbara Gr{\"u}necker and Sebastian F. Kaltwasser and Anne Catherin Zappe and Benedikt T. Bedenk and Y Bicker and Victor I. Spoormaker and Carsten T. Wotjak and Michael Czisch},
  journal={NMR in biomedicine},
  year={2013},
  volume={26 5},
  pages={542-56}
}
Manganese-enhanced MRI has recently become a valuable tool for the assessment of in vivo functional cerebral activity in animal models. As a result of the toxicity of manganese at higher dosages, fractionated application schemes have been proposed to reduce the toxic side effects by using lower concentrations per injection. Here, we present data on regional-specific manganese accumulation during a fractionated application scheme over 8 days of 30 mg/kg MnCl2 , as well as on the clearance of… CONTINUE READING
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