Regional specialization within the intestinal immune system

  title={Regional specialization within the intestinal immune system},
  author={Allan McI Mowat and William W. Agace},
  journal={Nature Reviews Immunology},
The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and… 
The Intestinal Immune System
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