Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: A voxel-based analysis study

@inproceedings{Mallik2015RegionalPO,
  title={Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: A voxel-based analysis study},
  author={Shahrukh Mallik and N. Muhlert and R. S. Samson and Varun Sethi and Claudia A. M. Wheeler-Kingshott and David H. Miller and Declan T. Chard},
  booktitle={Multiple sclerosis},
  year={2015}
}
BACKGROUND In multiple sclerosis (MS), demyelination and neuro-axonal loss occur in the brain grey matter (GM). We used magnetic resonance imaging (MRI) measures of GM magnetisation transfer ratio (MTR) and volume to assess the regional localisation of reduced MTR (reflecting demyelination) and atrophy (reflecting neuro-axonal loss) in relapsing-remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS). METHODS A total of 98 people with MS (51 RRMS, 28 SPMS, 19… CONTINUE READING

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