Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs.

@article{Lee2000RegionalOA,
  title={Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs.},
  author={Y Hee Lee and Glen D. Leesman and Vijaya D. Makhey and H Yu and Peidi Hu and Barbara T. Perry and John P. Sutyak and Erik J. Wagner and Lisa M. Falzone and William Stern and Patrick J. Sinko},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2000},
  volume={50 2},
  pages={205-11}
}
The dose-dependent disposition, first pass hepatic elimination, and absorption pharmacokinetics (PK) of salmon calcitonin (sCT) were investigated in a canine Intestinal Vascular Access Port (IVAP) model. The PK of sCT were determined after intravenous (IV), subcutaneous (SC), portal venous (PV), and oral (PO) administration of sCT. Regional oral absorption of unformulated sCT was also evaluated by direct administration into the duodenum (ID), ileum (IL), and colon (IC) by means of surgically… CONTINUE READING

Similar Papers

Loading similar papers…