Regional ocular gentamicin levels after transcorneal and transscleral iontophoresis.

@article{Grossman1990RegionalOG,
  title={Regional ocular gentamicin levels after transcorneal and transscleral iontophoresis.},
  author={R E Grossman and David F. Chu and D. A. Lee},
  journal={Investigative ophthalmology & visual science},
  year={1990},
  volume={31 5},
  pages={
          909-16
        }
}
Transcorneal and transscleral iontophoresis were compared to subconjunctival injection (control) in the delivery of gentamicin into rabbit eyes. Gentamicin levels in the corena, aqueous, and vitreous were measured by a fluorescence polarization assay at various time intervals after treatment. A mean peak corneal concentration of 376.1 micrograms/ml was achieved 2 hr after transcorneal iontophoresis. This was significantly higher than the level obtained in control eyes (P = 0.016). A mean peak… CONTINUE READING

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