Regional manifestations and control of the immune system

  title={Regional manifestations and control of the immune system},
  author={S. Saadi and L. Wrenshall and Jeffey L Platt},
  journal={The FASEB Journal},
  pages={849 - 856}
  • S. Saadi, L. Wrenshall, Jeffey L Platt
  • Published 2002
  • Medicine, Biology
  • The FASEB Journal
  • Although immune responses are generally considered to be systemic, local events such as interaction of complement products with blood vessels and with inflammatory cells play a pivotal role in determining the nature and manifestations of immune responses. This paper will discuss how blood vessel physiology and immunity influence one another to reach homeostasis upon exposure to an infectious agent. We review new insights into the mechanisms by which the microenvironment of tissues protects… CONTINUE READING

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    Publications referenced by this paper.
    Complement-mediated regulation of tissue factor activity in endothelium
    • 276
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    Non-immunoglobulin activators of the complement system
    • 9
    The effects of extracellular pH on immune function
    • 628
    • Open Access
    The Instructive Role of Innate Immunity in the Acquired Immune Response
    • 1,766
    Transient perturbation of endothelial integrity induced by natural antibodies and complement
    • 229
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    • Open Access
    Organ-specific immune responses associated with infectious disease.
    • 151
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    • 77
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