Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects.

@article{Schlussman2011RegionalME,
  title={Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects.},
  author={Stefan D. Schlussman and Jared J. Cassin and Yao Zhang and Orna Levran and A. -S. Ho and Mary Jeanne Kreek},
  journal={Pharmacology, biochemistry, and behavior},
  year={2011},
  volume={100 1},
  pages={8-16}
}
We have previously shown strain and dose differences in heroin-induced behavior, reward and regional expression of somatostatin receptor mRNAs in C57BL/6J and 129P3/J mice. Using Real Time PCR we examined the effects of five doses of heroin on the levels of the transcripts of endogenous opioid peptides and their receptors and dopaminergic receptors in the mesocorticolimbic and nigrostriatal pathways in these same mice. Compared to C57BL/6J animals, 129P3/J mice had higher mRNA levels of Oprk1… CONTINUE READING