Regional localization within the bone marrow influences the functional capacity of human HSCs.

@article{Guezguez2013RegionalLW,
  title={Regional localization within the bone marrow influences the functional capacity of human HSCs.},
  author={Borhane Guezguez and Clinton Campbell and Allison L. Boyd and Francis Karanu and Fanny L. Casado and Christine Di Cresce and Tony J. Collins and Zoya Shapovalova and Anargyros Xenocostas and Mickie Bhatia},
  journal={Cell stem cell},
  year={2013},
  volume={13 2},
  pages={
          175-89
        }
}
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell types. However, the composition and role of the human BM HSC niche have not been investigated. Here, using human bone biopsy specimens, we provide evidence of HSC propensity to localize to endosteal regions of the trabecular bone area (TBA). Through functional xenograft transplantation, we found that human HSCs… CONTINUE READING

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