Regional localization of an X-linked mental retardation gene to Xp21.1-Xp22.13 (MRX38).

@article{Schutz1996RegionalLO,
  title={Regional localization of an X-linked mental retardation gene to Xp21.1-Xp22.13 (MRX38).},
  author={Chris K Schutz and Elizabeth J. Ives and Maryse Chalifoux and L Maclaren and Sandra N Farrell and Paula D. Robinson and B. N. White and J. A. Holden},
  journal={American journal of medical genetics},
  year={1996},
  volume={64 1},
  pages={89-96}
}
A gene responsible for X-linked mental retardation with macrocephaly and seizures (MRX38) in a family with five affected males in three generations was localized to Xp21.1-p22.13 by linkage analysis. Recombination events placed the gene between DXS1226 distally and DXS1238 proximally, defining an interval of approximately 14 cM. A peak lod score of 2.71 was found with several loci in Xp21.1 (DXS992, DXS1236, DXS997, and DXS1036) at a recombination fraction of zero. The map intervals of 5 X… CONTINUE READING