Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

@article{Ibez1998RegionalGM,
  title={Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.},
  author={Vicente Ib{\'a}{\~n}ez and Pietro Pietrini and Gene E. Alexander and Maura L. Furey and Diane Teichberg and J C Rajapakse and Stanley I. Rapoport and Mark B. Schapiro and Barry Horwitz},
  journal={Neurology},
  year={1998},
  volume={50 6},
  pages={1585-93}
}
OBJECTIVE To determine whether the hypometabolism observed in PET images of patients with Alzheimer's disease (AD) is due entirely to brain atrophy. BACKGROUND Reduced brain glucose metabolism in AD patients measured using PET has been reported by numerous authors. Actual glucose metabolic values in AD may be reduced artificially because of brain atrophy, which accentuates the partial volume effect (PVE) on data collected by PET. METHODS Using segmented MR images, we corrected regional… CONTINUE READING
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