Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents.

@article{Lieberman1998RegionalGT,
  title={Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents.},
  author={Jay R. Lieberman and Lu Q Le and L Wu and Gerald A. M. Finerman and Arnold J. Berk and Owen N Witte and Susan Stevenson},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1998},
  volume={16 3},
  pages={
          330-9
        }
}
The ability to continuously deliver osteoinductive proteins to a specific anatomic site would facilitate the treatment of fracture nonunions and other clinical problems associated with bone loss. We have developed a murine model of regional gene therapy. A bone-marrow stromal cell line infected with an adenovirus expressing recombinant bone morphogenetic protein-2 cDNA secreted biologically active bone morphogenetic protein-2. These bone morphogenetic protein-2-producing cells were able to… CONTINUE READING

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