Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury.

@article{Dash2000RegionalEA,
  title={Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury.},
  author={Pramod K Dash and Sara A Mach and Anthony N. Moore},
  journal={Journal of neurotrauma},
  year={2000},
  volume={17 1},
  pages={69-81}
}
Prostaglandins, potent mediators of inflammation, are generated from arachidonic acid (AA) via the action of cyclooxygenase-1 and -2 (COX-1 and COX-2). In this study, we report that lateral cortical impact injury in rats significantly increases COX-2 protein levels both in the cortex surrounding the injury site and the ipsilateral hippocampus. COX-2 protein level was elevated as early as 3 h postinjury and persisted for up to 3 days. Increases in immunoreactivity were detected not only in the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…