Regional enteritis and HLA concordance in multiple siblings


A familial predisposition to ulcerative colitis and Crohn's disease is well established, and linkage of a susceptibility gene to the HLA gene locus has been postulated. We report here a family of five children, at least four and probably all five of whom have Crohn's disease. HLA studies of four of the five showed three with the same paternal haplotypes (A2… (More)
DOI: 10.1007/BF01296752


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