Regional effects of autonomic agents on ion transport across excised canine airways.

@article{Boucher1982RegionalEO,
  title={Regional effects of autonomic agents on ion transport across excised canine airways.},
  author={Richard C. Boucher and John T. Gatzy},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1982},
  volume={52 4},
  pages={893-901}
}
The effects of cholinergic and adrenergic agonists and antagonists on ion transport and bioelectric properties of excised canine trachea, main-stem bronchi, and subsegmental bronchi were studied. Acetylcholine (ACh) induced in bronchi a dose-dependent reduction in net Na+ absorption, maximal (30%) at 10(-5) M, that reflected a raised Na+ flux from submucosa to mucosa. Because conductance (G) did not change we speculate that the increased flow in the "passive" direction represents the induction… CONTINUE READING
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