Regional effects of aging on dopaminergic function in the Fischer-344 rat.

@article{Friedemann1992RegionalEO,
  title={Regional effects of aging on dopaminergic function in the Fischer-344 rat.},
  author={Marilyn N. Friedemann and Greg A. Gerhardt},
  journal={Neurobiology of aging},
  year={1992},
  volume={13 2},
  pages={325-32}
}
To examine the consequences of aging on nigrostriatal (A9) and mesolimbic (A10) dopamine (DA) function, neurochemical and behavioral measurements were performed in male Fischer-344 rats 6, 12, 18, 24, and 30 months old. Regional analyses of dopaminergic overflow and uptake processes were examined using high-speed (5 Hz) in vivo electrochemical recordings and local drug application techniques. When potassium was used to elicit the presynaptic overflow of dopamine (DA) in striatal areas… CONTINUE READING
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