Regional doxorubicin delivery reduces testicular toxicity.

  title={Regional doxorubicin delivery reduces testicular toxicity.},
  author={R C Lui and M C Laregina and D R Herbold and Jeffrey A Stern and F E Johnson},
  journal={The Journal of surgical research},
  volume={43 3},
Many anti-cancer drugs cause infertility. Regional delivery of these agents is a potential method to avoid this problem. We investigated the protective effect of normothermic testicular circulatory arrest on gonadal toxicity during doxorubicin administration in the Sprague-Dawley rat. Four groups of eight rats each were used. Animals in group 1 received no… CONTINUE READING