Regional distribution of the anticonvulsant and behavioural effects of bicuculline injected into the pontine reticular formation of rats.

@article{Shehab1997RegionalDO,
  title={Regional distribution of the anticonvulsant and behavioural effects of bicuculline injected into the pontine reticular formation of rats.},
  author={Safa Aldeen S Shehab and Joseph V. Guadagno and K. Ferguson and Peter Redgrave},
  journal={The European journal of neuroscience},
  year={1997},
  volume={9 9},
  pages={1875-84}
}
Previous experimental work has established that activation of sites in the dorsal midbrain can suppress tonic hindlimb extension in the electroshock model of epilepsy. The most sensitive region for this effect is centred on the intercollicular area and is referred to as the dorsal midbrain anticonvulsant zone (DMAZ). Subsequent experiments have shown that the ipsilateral descending projection from this region to the ventrolateral pons is critically involved in mediating its tonic seizure… CONTINUE READING