Regional distribution of mitochondrial dysfunction and apoptotic remodeling in pacing-induced heart failure.

Abstract

BACKGROUND Specific myocardial mitochondrial enzymatic dysfunction and apoptotic remodeling occur in pacing-induced heart failure. We sought to define their regional distribution and molecular basis in the failing heart. METHODS AND RESULTS Enzyme dysfunction was assessed in mitochondrial subpopulations and immunoblot analysis was performed using… (More)
DOI: 10.1016/j.cardfail.2009.04.010

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