Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.

@article{Parkkinen2003RegionalDO,
  title={Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.},
  author={L Parkkinen and Hilkka Soininen and Irina Alafuzoff},
  journal={Journal of neuropathology and experimental neurology},
  year={2003},
  volume={62 4},
  pages={363-7}
}
The amygdaloid complex (AC) was found highly vulnerable to alpha-synuclein (alphaS) pathology in both familial and sporadic Alzheimer disease (AD), and recently, incidental Lewy bodies (LBs) were identified primarily in the lower brainstem. This challenges the traditional view that the substantia nigra (SN) is the region that is predominately affected in the spectrum of LB disorders. We examined the immunoreactivity of alphaS in the SN, the nucleus basalis of Meynert (nbM), and the AC in 904… CONTINUE READING

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