Regional distribution and clinical correlates of white matter structural damage in Huntington disease: a tract-based spatial statistics study.

@article{Nave2010RegionalDA,
  title={Regional distribution and clinical correlates of white matter structural damage in Huntington disease: a tract-based spatial statistics study.},
  author={Riccardo Della Nave and Andrea Ginestroni and Carlo Tessa and Marco Giannelli and Silvia Piacentini and Massimo Filippi and Mario Mascalchi},
  journal={AJNR. American journal of neuroradiology},
  year={2010},
  volume={31 9},
  pages={1675-81}
}
BACKGROUND AND PURPOSE HD entails damage of the WM. Our aim was to explore in vivo the regional volume and microstructure of the brain WM in HD and to correlate such findings with clinical status of the patients. MATERIALS AND METHODS Fifteen HD gene carriers in different clinical stages of the disease and 15 healthy controls were studied with T1-weighted images for VBM and DTI for TBSS. Maps of FA, MD, and λ∥ and λ⊥ were reconstructed. RESULTS Compared with controls, in addition to… CONTINUE READING