Regional differences in the placental levels of oxidative stress markers in pre-eclampsia.

Abstract

OBJECTIVE To examine placental malondialdehyde (MDA), catalase, and glutathione peroxidase (GPx) levels in four placental regions among women with and without pre-eclampsia. METHODS A cross-sectional study was conducted among women aged 18-35 years with a singleton pregnancy in Pune, India, between May 3, 2013, and June 16, 2014. Three groups were enrolled: normotensive; pre-eclampsia, delivered at term; and pre-eclampsia, delivered preterm. Samples were collected from the central and peripheral placental regions (maternal and fetal sides) immediately after delivery. RESULTS A total of 60 women were enrolled (35 normotensive; 11 with pre-eclampsia delivered at term; 14 with pre-eclampsia, delivered preterm). MDA levels were higher in all regions of the placenta among the pre-eclampsia versus normotensive groups (P<0.01). MDA levels were higher in the central maternal region than in the central fetal region in the preterm pre-eclampsia group (P=0.023). The MDA levels in the central maternal region were also higher in the preterm than in the term pre-eclampsia group (P=0.014). Catalase activity was lower in the peripheral maternal (P=0.036) and fetal (P=0.050) regions in the preterm pre-eclampsia group versus the normotensive group. The activity of GPx was higher in the peripheral maternal region than in the central fetal region in the normotensive group (P=0.033). CONCLUSION Pre-eclampsia might be characterized by differential placental oxidative stress and antioxidant enzyme activity.

DOI: 10.1016/j.ijgo.2015.03.001
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@article{Sahay2015RegionalDI, title={Regional differences in the placental levels of oxidative stress markers in pre-eclampsia.}, author={Akriti S. Sahay and Deepali P. Sundrani and Girija N. Wagh and Savita S. Mehendale and Sadhana Ramchandra Joshi}, journal={International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics}, year={2015}, volume={129 3}, pages={213-8} }