Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani.

@article{Melby1998RegionalDI,
  title={Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani.},
  author={Peter C Melby and Yan-qing Yang and Jun Cheng and Wei Zhao},
  journal={Infection and immunity},
  year={1998},
  volume={66 1},
  pages={18-27}
}
Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected in the skin developed no detectable visceral parasitism, whereas intravenous inoculation resulted in hepatosplenomegaly and an increasing visceral parasite burden. Spleen cells from mice with locally… CONTINUE READING