Regional differences in nitric oxide-dependent vascular responses to somatostatin.

  title={Regional differences in nitric oxide-dependent vascular responses to somatostatin.},
  author={L{\'a}szl{\'o} D{\'e}zsi and M{\'a}ty{\'a}s Szentiv{\'a}nyi and Gabriella D{\"o}rnyei and Lior Loewenstein and M{\'a}ria Farag{\'o} and Tivadar Tulassay and Emil Monos},
  journal={Physiological research},
  volume={45 4},
The mechanisms of the vascular effects of somatostatin (ST) are not well known. This study compares the direct effect of ST in different vascular regions and species. Isolated perfused segments of the cat superior mesenteric artery in vitro did not exhibit a vascular response in the resting state, however, ST-induced vasodilatation was observed with norepinephrine preconstriction. In contrast, ST only slightly dilated superior mesenteric vein segments. In the artery, NG-nitro-L-arginine… CONTINUE READING