Regional differences in effects of 4-aminopyridine within the sinoatrial node.

Abstract

4-Aminopyridine (4-AP)-sensitive transient outward current ( I to) has been observed in the sinoatrial node, but its role is unknown. The effect of block of I to by 5 mM 4-AP on small ball-like tissue preparations (diameter ∼0.3-0.4 mm) from different regions of the rabbit sinoatrial node has been investigated. 4-AP elevated the plateau, prolonged the… (More)
DOI: 10.1152/ajpheart.1998.275.4.H1158

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