Imaging changes associated with cognitive abnormalities in Parkinson’s disease
BACKGROUND AND PURPOSE The pathology of neuropsychological deficits in Parkinson's disease (PD) is incompletely defined. METHODS We investigated cortical thickness and neuropsychological performances in non-demented patients with PD and healthy controls. RESULTS Patients showed significant cortical thinning in right middle temporal and left fusiform cortices. Verbal memory performance was related with left fusiform thinning. CONCLUSIONS Cognitive and cortical changes in non-demented patients with PD are detectable and clearly related.