Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes.

@article{Chang2015RegionalCD,
  title={Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes.},
  author={Yu-Ling Chang and T L Chen and Yao-Chia Shih and Ming-Jang Chiu and S Yan and W Y I Tseng},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={44 1},
  pages={
          125-38
        }
}
Amnestic mild cognitive impairment (aMCI), which has a high risk of progression to Alzheimer's disease (AD), can be classified into single domain (S-aMCI) and multiple domain (M-aMCI) subtypes. We investigated the integrity of regional gray matter and segments of the cingulum bundle with diffusion spectrum imaging tract-specific analysis, and their relationships to neuropsychological functioning, in 46 individuals with aMCI (S-aMCI n = 24; M-aMCI n = 22) and 36 healthy controls (HC). Results… CONTINUE READING