Regional chemotherapy of maxillofacial malignant melanoma with intracarotid artery infusion of DTIC.

Abstract

Six intracarotid artery infusions of DTIC were performed in 4 patients with invasive malignant melanoma of the maxillo-facial region. A total dose of 3.5 to 7 g was well tolerated. Only 1 patient who received 9.5 g in 25 days developed a reversible bone marrow depletion. Two out of the 4 patients presented a transient 50% tumor surface regression, but no response was seen after the second infusion. Of the 2 remaining patients, 1 had no measurable effect and 1 experienced tumor progression.

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@article{Jortay1977RegionalCO, title={Regional chemotherapy of maxillofacial malignant melanoma with intracarotid artery infusion of DTIC.}, author={A. M. Jortay and Ferdy J. Lejeune and Yvon Kenis}, journal={Tumori}, year={1977}, volume={63 3}, pages={299-302} }