Regional cerebral glutamate concentrations and chronic tobacco consumption.

  title={Regional cerebral glutamate concentrations and chronic tobacco consumption.},
  author={Jean Gallinat and Florian Schubert},
  volume={40 2},
INTRODUCTION Increasing evidence indicates a crucial role of glutamate in the brain reward system and nicotine addiction. Because the pertinent models involve frontal and hippocampal glutamatergic projections, our goal was to investigate cerebral glutamate concentrations in healthy subjects with different smoking behavior. METHODS Glutamate was measured with proton magnetic resonance spectroscopy at 3 tesla in the left hippocampus and anterior cingulate cortex (ACC) in 13 chronic tobacco… CONTINUE READING