Regional cerebral glucose metabolism and postmortem pathology in Alzheimer’s disease

  title={Regional cerebral glucose metabolism and postmortem pathology in Alzheimer’s disease},
  author={Ruediger Mielke and R. K. Schroeder and Gereon R. Fink and Josef Kessler and Karl Herholz and W. -D. Heiss},
  journal={Acta Neuropathologica},
In four patients with an antemortem diagnosis of probable Alzheimer’s disease (AD) regional cerebral glucose metabolism (rCMRGl) was studied prospectively by positron emission tomography (PET) and compared with postmortem semiquantitative neuropathology. The interval between the last PET study and autopsy was 1.3±0.8 years. In comparison with age-matched controls, the AD patients showed predominant temporoparietal hypometabolism spreading to other cortical and subcortical regions during serial… CONTINUE READING


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