Regional cerebral blood flow effects of nicotine in overnight abstinent smokers.

@article{Zubieta2001RegionalCB,
  title={Regional cerebral blood flow effects of nicotine in overnight abstinent smokers.},
  author={J K Zubieta and Umberto Lombardi and Satoshi Minoshima and Sally K. Guthrie and Lisong Ni and Linda E Ohl and Robert A. Koeppe and Edward F. Domino},
  journal={Biological psychiatry},
  year={2001},
  volume={49 11},
  pages={906-13}
}
BACKGROUND Most people agree that dependence to tobacco is mediated by the effects of nicotine on the central nervous system, albeit the neural pathways involved are not clearly delineated. We investigated the effect of nasal nicotine spray on regional cerebral blood flow (rCBF) in a sample of habitual smokers, with H2 15O and positron emission tomography (PET). METHODS Eighteen volunteer smokers were studied after 12 hours of smoking deprivation. Regional cerebral blood flow measures were… CONTINUE READING