Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat.

@article{Cummings1976RegionalBI,
  title={Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat.},
  author={M G Cummings and Peter B. Soeters and J. Howard James and John M. Kean and Josef E. Fischer},
  journal={Journal of neurochemistry},
  year={1976},
  volume={27 2},
  pages={
          501-9
        }
}
— Four weeks after portacaval anastomosis in the rat. a profound change in the pattern of the plasma neutral ammo acids occurred. These changes were accompanied by marked regional changes in brain trvptophan. 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindoleacetic acid). Tryptophan was elevated in all the regions studied as was 5-HIAA. 5-Hydroxytryptamine was significantly elevated only in midbrain and medulla pons. A small but significant increase in free trvptophan concentration in… CONTINUE READING

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