Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat

@article{Beijsterveldt1994RegionalBD,
  title={Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat},
  author={Ludy E. C. van Beijsterveldt and Rita J. F. Geerts and Jos{\'e}e E. Leysen and Anton A. P. H. Megens and H. Van den Eynde and Willem E. G. Meuldermans and Jozef J. P. Heykants},
  journal={Psychopharmacology},
  year={1994},
  volume={114},
  pages={53-62}
}
Risperidone is a new benzisoxazole antipsychotic. 9-Hydroxy-risperidone is the major plasma metabolite of risperidone. The pharmacological properties of 9-hydroxy-risperidone were studied and appeared to be comparable to those of risperidone itself, both in respect of the profile of interactions with various neurotransmitters and its potency, activity, and onset and duration of action. The absorption, plasma levels and regional brain distribution of risperidone, metabolically formed 9-hydroxy… CONTINUE READING

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