Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the swedish mutation

@article{Strazielle2003RegionalBC,
  title={Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the swedish mutation},
  author={C. Strazielle and C. Sturchler-Pierrat and M. Staufenbiel and R. Lalonde},
  journal={Neuroscience},
  year={2003},
  volume={118},
  pages={1151-1163}
}
  • C. Strazielle, C. Sturchler-Pierrat,, +1 author R. Lalonde
  • Published 2003
  • Biology, Medicine
  • Neuroscience
  • Cytochrome oxidase activity was examined in a transgenic mouse model of Alzheimer's disease with overexpression of the 751 amino acid isoform of beta-amyloid precursor protein with the Swedish mutation under control of the murine thy-1 promoter. The neuritic plaques, abundantly localized in the hippocampus and anterior neocortical areas, showed a core devoid of enzymatic activity surrounded by higher cytochrome oxidase activity at the sites of the dystrophic neurites and activated glial cells… CONTINUE READING
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