Regional assignment of the steroid sulfatase-X-linked ichthyosis locus: implications for a noninactivated region on the short arm of human X chromosome.

@article{Mohandas1979RegionalAO,
  title={Regional assignment of the steroid sulfatase-X-linked ichthyosis locus: implications for a noninactivated region on the short arm of human X chromosome.},
  author={Thuluvancheri Mohandas and Larry J. Shapiro and Robert S. Sparkes and Maryellen C. Sparkes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 11},
  pages={5779-83}
}
The expression of steroid sulfatase (SS; sterol-sulfatase; sterol-sulfate sulfohydrolase, EC 3.1.6.2), a microsomal enzyme that catalyzes the hydrolysis of a variety of 3beta-hydroxysteroid sulfates, was evaluated in mouse-human hybrid clones. The mouse parental line, A9, was found to have little SS as determined by activity measurements. Human SS can be separated from mouse SS by electrophoresis. Two human fibroblast lines, one carrying an X/13 translocation [46,X,t(X;13)(p22;q12)] and the… CONTINUE READING

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