Regional and time-resolved mutation patterns of the human genome

  title={Regional and time-resolved mutation patterns of the human genome},
  author={Peter F. Arndt and Terence Hwa},
  volume={20 10},
MOTIVATION Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. RESULTS Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic… CONTINUE READING

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