Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy.

@article{Biagini2001RegionalAS,
  title={Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy.},
  author={Giuseppe Biagini and Kazimierz Babinski and Massimo Avoli and Mieczyslaw Marcinkiewicz and Philippe S{\'e}gu{\'e}la},
  journal={Neurobiology of disease},
  year={2001},
  volume={8 1},
  pages={45-58}
}
Acid-sensing ion channels (ASICs) constitute a recently discovered family of excitatory cation channels, structurally related to the superfamily of degenerin/epithelial sodium channels. ASIC1b and ASIC3 are highly expressed in primary sensory neurons and are thought to play a role in pain transmission related to acidosis. ASIC1a, ASIC2a, and ASIC2b are also… CONTINUE READING