Regional and developmental variations in metabolite concentration in the rat brain and eye: A study using1H NMR spectroscopy and high performance liquid chromatography

@article{Florian1996RegionalAD,
  title={Regional and developmental variations in metabolite concentration in the rat brain and eye: A study using1H NMR spectroscopy and high performance liquid chromatography},
  author={C-L. Florian and Dr. S. R. Williams and Kishore Kumar Bhakoo and Mark Noble},
  journal={Neurochemical Research},
  year={1996},
  volume={21},
  pages={1065-1074}
}
Regional and developmental changes in metabolite concentrations were measured by1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to adult, while the related compound N-acetylaspartylglutamate was highest in adult optic nerve. Creatine and choline-containing compounds were present in all regions throughout… CONTINUE READING
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