Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

@article{Miksys2002RegionalAC,
  title={Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.},
  author={Sharon Miksys and Yushu Rao and Ewa B. Hoffmann and Deborah C. Mash and Rachel F. Tyndale},
  journal={Journal of neurochemistry},
  year={2002},
  volume={82 6},
  pages={1376-87}
}
Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally acting drugs and toxins. As ethanol can induce CYP2D in rat brain, we hypothesized that CYP2D6 expression is higher in brains of human alcoholics. We examined regional and cellular expression of CYP2D6 mRNA and protein by RT-PCR, Southern blotting, slot blotting, immunoblotting and immunocytochemistry. A significant correlation was found between mean mRNA and CYP2D6… CONTINUE READING

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