Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.

@article{Halbach2006RegionalAA,
  title={Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.},
  author={Oliver von Bohlen Und Halbach and Sonja Krause and Diego Luis Medina and Carla Sciarretta and Liliana Minichiello and Klaus Unsicker},
  journal={Biological psychiatry},
  year={2006},
  volume={59 9},
  pages={793-800}
}
BACKGROUND Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during… CONTINUE READING

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