Regional alterations of dopamine and its metabolites in rat brain following portacaval anastomosis

Abstract

Hyperammonemia and changes in brain monoamine metabolism have been proposed to contribute to the pathogenesis of the neuropsychiatric symptoms characteristic of human portal-systemic encephalopathy (PSE) resulting from chronic liver disease. Portacaval anastomosis (PCA) in the rat leads to sustained hyperammonemia and mild encephalopathy. In order to… (More)
DOI: 10.1007/BF00995156

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