Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.

@article{Wang2006RegionalAO,
  title={Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.},
  author={Yan Wang and Dejan Juric and Brian A. Francisco and Ron X. Yu and George E. Dur{\'a}n and Gary K. Chen and Xin Chen and Branimir Sikic},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 4},
  pages={365-74}
}
Taxanes are important drugs in the treatment of ovarian and other cancers, but their efficacy is limited by intrinsic and acquired drug resistance. Expression of the multidrug transporter P-glycoprotein, encoded by the MDR1 (ABCB1) gene, is one of the causes of clinical drug resistance to taxanes. To study the mechanisms of MDR1 activation related to taxanes, we established 11 multidrug-resistant variants from six ovarian cancer cell lines by continuous exposure to either paclitaxel or… CONTINUE READING