Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease.

@article{Block2002RegionalNR,
  title={Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease.},
  author={Wolfgang Block and Frank Jessen and F Tr{\"a}ber and Sebastian Flacke and Christoph Manka and Rolf M. J. N. Lamerichs and Ewald Keller and Reinhard Heun and H. O. Schild},
  journal={Archives of neurology},
  year={2002},
  volume={59 5},
  pages={828-34}
}
OBJECTIVE To detect regional metabolic changes that resemble the expected spatial pattern of neuronal loss in patients with Alzheimer disease (AD). METHODS Thirty-four patients with AD and 22 healthy control subjects were included in the study. Single-slice fast proton spectroscopic imaging was performed in parallel angulation to the temporal lobes. Proton spectra were selected from the hippocampus, the lateral temporal lobe, and the occipital lobe of both hemispheres to determine metabolite… CONTINUE READING

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