Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

@article{Kuhar1973RegionalDO,
  title={Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain},
  author={Michael J. Kuhar and Candace B. Pert and Solomon H. Snyder},
  journal={Nature},
  year={1973},
  volume={245},
  pages={447-450}
}
The frequency of opiate receptors varies dramatically throughout the human and monkey brain. The authors describe a relationship between the distribution of opiate receptors and of neurotransmitters. 

Opiate Receptors

Abstract Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The ...

Opiate receptor revisited.

Tritiated naloxone, a powerful opiate antagonist, binds to an opiate receptor of mammalian brain and guinea pig intestine and confined to nervous tissue.

Endogenous opiates: Through 1978

Naloxone binding in the frontal cortex of postmortem human brain

Neurotransmitter activity in the brain: Focus on the opiate receptor

The detailed localization of opiate receptor and enkephalins throughout the brain helps to clarify mechanisms of pain perception and emotional regulation.

Opiate receptor distribution in the cerebral cortex of the Rhesus monkey.

The distribution of opiate receptors in the cerebral cortex of the rhesus monkey (Macaca mulatta) was determined by autoradiographic visualization of [3H]naloxone binding to tissue sections. Naloxone
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References

SHOWING 1-10 OF 15 REFERENCES

Opiate Receptor: Demonstration in Nervous Tissue

Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine that closely parallels their pharmacological potency.

THE DISTRIBUTION OF TRYPTOPHAN HYDROXYLASE IN CAT BRAIN

Abstract— The distribution of tryptophan hydroxylase in the cat brain was investigated and found to parallel roughly the distribution of serotonin. The most active areas are the caudate nucleus,

Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.

In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions.

REGIONAL DISTRIBUTION OF γ‐AMINOBUTYRIC ACID (GABA) IN BRAIN OF THE RHESUS MONKEY *

The concentrations of γ‐aminobutyric acid (GABA) in twenty different regions of Rhesus monkey brain were studied and indirect evidence supporting an inhibitory transmitter role for GABA is discussed.

Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.

Etorphine, the most potent narcotic analgesic known, was labeled with tritium by catalytic exchange. This drug exhibits stereospecific, saturable binding to rat-brain homogenate. At saturation, the

Brain sites of precipitated abstinence in morphine-dependent rats.

  • E. WeiH. LohE. Way
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1973
The brains of morphine-dependent rats were explored for areas sensitive to naloxone-precipitated withdrawal and the neuroanatomical pathways related to opioid dependence were discussed.

Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake.

The uptake activity of radioactive l-tryptophan, dopamine and l-norepinephrine in animals with raphe lesions was not reduced, suggesting that only 5-HT was uniquely accumulated by nerve endings of the raphe neurons.

Effect of lateral hypothalamic lesions on uptake of norepinephrine by brain homogenates.

A reduced in vitro uptake of norepinephrine demonstrates a specific functional interrelationship between the lateral hypothalamus and norpinephrine-containing nerve fibers throughout the telencephalon, one which may involve single fibers travelling through the hypothalamus to the telENCEphalon.