Regional Distribution of Aerosol Deposition in Rat Lungs Using Magnetic Resonance Imaging

@article{Oakes2013RegionalDO,
  title={Regional Distribution of Aerosol Deposition in Rat Lungs Using Magnetic Resonance Imaging},
  author={Jessica M Oakes and Miriam Scadeng and Ellen C Breen and G. Kim Prisk and Chantal Darquenne},
  journal={Annals of Biomedical Engineering},
  year={2013},
  volume={41},
  pages={967-978}
}
The toxic or therapeutic effect of an inhaled aerosol is highly dependent upon the site and extent of deposition in the lung. A novel MRI-based method was used to quantify the spatial distribution of particles in the rat lung. Rats were exposed to 0.95 μm-diameter iron oxide particles in a controlled manner (N = 6) or to particle-free air (N = 6). Lungs were fixed in 3% glutaraldehyde by vascular perfusion, excised and imaged in a 3T scanner using a gradient-echo imaging protocol. The signal… CONTINUE READING

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