Regional Differences in Reactive Gliosis Induced by Substrate-Bound β-Amyloid

  title={Regional Differences in Reactive Gliosis Induced by Substrate-Bound $\beta$-Amyloid},
  author={Ahmet H{\"o}ke and David R. Canning and Charles J. Malemud and Jerry Silver},
  journal={Experimental Neurology},
Abstract Regions of gliosis surround deposits of (β-amyloid peptide (βAP) in senile plaques of Alzheimer's disease (AD). The association between reactive astrocytes and βAP in senile plaques is most pronounced in cortex and hippocampus but not at other anatomical sites of βAP deposition. We hypothesized that this region-specific pathology in AD could be attributed to differences in glial reactivity in different parts of the central nervous system (CNS). To test this hypothesis, we assayed… 
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