Regional Cerebral Blood Flow (cbf) in a Rat Model Parallels Changes in Human Perinatal Hypoxicischemic Encephalopathy (hie)

Abstract

Exposure of immature rats to 8% O2 after unilateral carotid artery ligation (UCL) is used as a model of perinatal HIE. The procedure causes reproducible metabolic, neurochemical and histopathological changes lateralized to forebrain on the side of ligation. Tissue effects are attributed to a combination of hypoxemia and relative ischemia, but CBF has not… (More)
DOI: 10.1203/00006450-198404001-01704

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